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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often described by their focus on practical aspects of designing a study, including recruitment and consent, adherence and the use routinely available equipment.
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Pragmatic is a software developer that offers a broad range of casino games available on online gambling platforms. Its iGaming software is used by leading operators and land based casinos. The company provides front-end design tools, analysis, promotions, marketing, payment systems, security, customer service and bug reporting. In addition, the company provides its users a safe environment that features high-quality graphics and games.
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A pragmatic study that involves a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is vital for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However too much heterogeneity could lead to problems with the design of the trial.
Pragmatic Play is also a major player in the live casino market, providing an extensive selection of classic table games such as Blackjack and Roulette in various versions. The live studios of the company in Romania and Malta offer customers an authentic experience in gambling as well as a broad range of virtual betting options. The company also has created several interactive game shows to make online gambling enjoyable. Some of these shows feature a live host, while others are hosted by famous personalities from the industry.
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Pragmatic Play offers not only mobile-friendly slot machines, but also live casino and table games. The company is licensed by a variety of regulatory bodies such as Malta Gaming Authority and UK Gambling Commission. The games are protected by the latest encryption technology, and the company's security team is always available to assist players solve any issues they may have.
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Legality
Pragmatic Play is renowned for its top-quality games and for offering an exceptional user experience. Its software can be used on mobile devices as well as in various languages. Despite its relatively young age, it has already established itself as a premier gaming platform for casinos. Its latest releases include Wolves which is a five-reel video slot with a healthful RTP and impressive graphics. The other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can also be used to determine the causal relationship between an intervention and its effects. However, they should not be used as a substitute for explanation studies.
The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also suggested the framework for pragmatic trials, called PRECIS.2 This tool attempted to define the elements of a pragmatic trial which includes the recruitment process, the design and implementation of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind, however, that the majority were conducted in primary-care settings.